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Rather than signaling when to sleep, it influences how well you sleep once you get there

Headache represents another occasionally reported effect, potentially related to the peptide's vasodilatory properties

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Hermens et al

Not a Long-Term Solution for Functional Improvement: Despite short-term pain relief, ESIs do not show statistically significant advantages over conservative treatment in terms of long-term functional improvement (6 months to 1 year) or even short-to-intermediate term functional improvement (1 to 6 months)